All participants underwent FDG-PET brain scan to provide data for voxel-based morphometric analysis. Apathy was defined using Robert's 2009 diagnostic criteria, and specific apathy characteristics were assessed with the Lille Apathy Rating Scale.
Methodsįorty-two bvFTD, 42 AD, and 30 healthy volunteers without cognitive or behavioral complaints were included. Our main purposes were to compare the clinical apathy profile from patients with bvFTD and AD and analyze the relationship between apathy and brain metabolism measured using positron emission tomography imaging with 18F fluorodeoxyglucose (FDG-PET). Clinical apathy expression and neuroanatomical basis of apathy seem to differ between behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD), although evidence is scarce and poorly understood. Apathy is one of the most common and disabling syndromes of dementia.
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